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Ccleaner & Malwarebytes as a combo worked wonders for every single computer I've ever used. Run them every couple months and it should be smooth sailing. However, sometimes when computers go on a while, they start to accumulate many conflicting registry files. You may need to clean registry too but this part is a pain, many people just resort to reformat at this point. Finally, it may be hardware related, have you ran a hard drive test? Defraging the HD may help.
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